Uplift - Medical technology innovation
Uplift - Medical technology innovation
Partnership

Enhanced technology for our heart

by Isabelle Vloemans
11 June 2024
ETH Zurich Foundation, Enhanced technology for our heart
© Christian Marquardt 2024
Partnership

Enhanced technology for our heart

by Isabelle Vloemans
11 June 2024

Renowned cardiac surgeon Volkmar Falk is making strides at the intersection of clinical practice and engineering sciences. ETH is his long-standing partner.

You’re Director of the German Heart Center Berlin and travel to Zurich several times a year. Conversely, ETH researchers travel to Berlin, and our students do internships with you. How did these close connections come about?

VOLKMAR FALK – From 2009 to 2014, I held the position of Director of Cardiovascular Surgery at University Hospital Zurich. Even before that, I was drawn to the field of engineering and was exploring topics like robotics and computer-assisted surgery. When I arrived in Zurich, I presented myself to ETH in the very first week, our talks at that time focussing on a specific project to model catheter-based heart valve procedures. However, in parallel, the idea of developing a novel artificial heart emerged, as the technology still in use from the 1980s continues to exhibit problems. I managed to get an array of ETH researchers excited by the idea and – under the umbrella of Hochschulmedizin Zürich – we formed a consortium of around 10 professorships.

ETH Zurich Foundation, Enhanced technology for our heart
Minimally invasive surgery for mitral valve repair.
© Külker/DHZC

We set up multiple fundamental research projects in fields like sensor technology, control engineering and biocompatible artificial surfaces and gained valuable insights into ways of optimising existing cardiac support systems. Since my move to Berlin in 2014, I’ve been working in Europe’s leading heart clinic. However, I still see Zurich as the most fertile ground for technological collaboration.

Your professorship in Translational Cardiovascular Technologies (TCT) was created in 2019 to institutionalise this successful collaboration at ETH. How much has been achieved for patients since then?

With minimal human resources – besides my 10 per cent position, there are two other roles – we and various ETH departments are working under the name “ETHeart” to develop innovative technologies for cardiovascular medicine. Our aim is to see these technologies find their way into clinical practice and save lives. But the hurdles are high: while bright minds can come up with technological solutions, the regulatory landscape in the medical field is extensive. Nonetheless, we’ve had certain successes, and these make me proud. One example is a project that culminated in the Hylomorph spin-off, in which we navigated the entire translational process from development to preclinical studies to clinical trials. Hylomorph has plans to launch an implant envelope on the market that’s expected to make a significant reduction to postoperative complications. Another is a project with the Department of Computer Science in which artificial intelligence is used to extract poor outcome predictors from routine intensive care data. It was from this basis that x-cardiac spin-off received approval for its product. It’s my belief that this technology will facilitate day-to-day medical practice in the future.

“I’m highly impressed by the ETH students I meet on internships here in Berlin. Such people will be ideally equipped for translational research in the future.”

Volkmar Falk

You’re also involved in teaching – what do you think of the ETH Bachelor of Human Medicine introduced in 2017?

I’m highly impressed by the students I meet on internships here in Berlin. Such people will be ideally equipped for translational research in the future because they’ll have an understanding of engineering and computer science, which is a completely different skillset to that of traditional medical students.

Funding for your lab is only secured until 2025 – why should private donors support the TCT lab?

Cardiovascular disease is the most common cause of death worldwide. Almost everyone has someone with heart disease in their family or circle of friends. Thanks to the combined expertise of ETH’s excellent engineering and biosciences and Europe’s leading institution for cardiovascular medicine, we can achieve a real impact – a unique opportunity!

Continuing the success story

In just four years, Volkmar Falk’s extremely lean professorship in Translational Cardiovascular Technologies has initiated 16 collaborative projects, contributed to two patents and co-supervised 15 doctoral students and two postdocs. It has participated in six preclinical translational trials and in three clinical studies with over 300 patients.

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