SonoSight

Brain tumor surgery remains a delicate balance between removing diseased tissue and preserving healthy brain areas. This challenge is particularly important for tumors located close to regions involved in movement, language, cognition, or essential vascular structures. Current focused ultrasound approaches remain limited by skull-induced acoustic distortion, dependence on MRI infrastructure, and complex clinical logistics.

With SonoSight, Pioneer Fellow Isaac Esteban is developing a compact intraoperative medical device that combines focused ultrasound therapy with real-time imaging guidance and treatment monitoring. Designed for use during open neurosurgery, the system aims to help clinicians localize superficial or cortical brain lesions, deliver acoustic energy precisely, and monitor the tissue response during treatment.

As part of the Pioneer Fellowship, Isaac will advance the existing prototype towards a more robust and translation-oriented system. The goal is to prepare the technology for preclinical development, strengthen its regulatory and intellectual-property roadmap, and establish the foundation for a future MedTech start-up.